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Automated Radiopharmaceutical Production System for PET Imaging

imigine automated production radiopharmaceuticals pet imaging theranostics PMB Alcen

By combining a 12 MeV cyclotron and an innovative radiochemistry room, iMiGiNE provides an unprecedented solution for research & medical centers. The ease-of-use, automation and versatility of this system allow healthcare professionals to break new ground in medical diagnostics and biological research.

Today, a limited access to specific molecules

Even though more than 200 molecules could be of clinical interest, only a few of them are currently used. 

The radiopharmaceuticals currently used in PET imaging are generally produced and distributed by major private centers, using a heavy and costly process. These centers produce radioactive atoms in large-sized cyclotrons and synthesize them with targeting agents of clinical interest, before testing and injecting them. Various financial, logistical and technical constraints are the underlying cause of the limited supply in radiotracers today, which has direct consequences on patient care. Health facilities are unable to use specific molecules, which would help better characterize the disease and eventually, provide patients with more adequate care and efficient treatments. 

iMiGiNE represents an alternative to these major constraints, by relocating the radiopharmaceutical production close to the patient, and by offering more specific molecules tailored to the patient's actual pathology and needs. 


On-site production of radiopharmaceuticals

iMiGiNE is a system designed for facilitated in-situ production of various radiopharmaceuticals on the same day. 

As a first step to the radiopharmaceutical production process, several radioisotopes, such as 18F, 11C and 68Ga are produced inside the cyclotron iMiTRACE. The robotized radiochemistry iMiLAB then carries out the radiosynthesis process, using microfluidic technology (labelling the targeting agent with a selected radioisotope). Quality control is finally completed through an automated process to test the synthesized molecule.